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Breast Cancer

Patients at moderate additional risk of developing breast cancer based on family history should be managed in secondary care (usually breast care services). Contact details for these services can be found at the end of this document. The genetic service is dedicated to seeing individuals at high additional risk of developing breast cancer due to a family history. Please see the latest NICE guidelines on Familial Breast cancer for guidance on whether your patient is at high risk.

  • The following is a brief summary of family histories where there may be a high additional risk of breast cancer:
  • A woman with an oestrogen/progesterone receptor and Her2 expression negative breast tumour (Triple negative) under the age of 40
  • An individual with a male breast cancer at any age plus one close relative with breast cancer from the same side of the family
  • An individual with two close relatives with breast cancer with an average age of diagnosis under 50 and who come from the same side of the family
  • An individual with three close relatives with breast cancer with an average age of diagnosis under 60 and who come from the same side of the family
  • An individual with four close relatives diagnosed at any age and who come from the same side of the family
  • An individual with a parent, sibling or child diagnosed with bilateral breast cancer before the age of 50
  • For bilateral breast cancer, count as 2 affected cases
  • The following is a brief summary of family histories where there may be a high additional risk of ovarian and or breast cancer:
  • A woman with a serous papillary ovarian cancer with or without a family history of breast cancer
  • An individual with one relative with ovarian cancer at any age plus one close relative with breast cancer before age 50, from the same side of the family
  • Two close relatives with ovarian cancer at any age from the same side of the family
  • One relative with ovarian cancer at any age plus two close relatives with breast cancer with an average age of diagnosis under 60 from the same side of the family
  • Please contact us if the following features are present in the family in addition to a family history of breast and or ovarian cancer:
  • Jewish ancestry
  • Sarcoma in a relative younger than age 45 years
  • Glioma or childhood adrenal cortical carcinoma

Referrals

If you are not sure whether to refer please contact us. A clinician is available to answer queries any time between Monday-Friday 8am-4pm, our telephone number is 02………

We are a large regional genetic service covering a population of nearly 2 million people. Inevitably there are a few local variations in service provision. The following are examples of secondary care services available in Anytown:

Anytown Amazing County Hospital

Another Amazing Hospital

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